Variations of energy metabolism and adenosine Triphosphatase activity in gastric mucosa in chronic atrophic gastritis rats with Qi deficiency and blood stasis syndrome and effect of Zhiweifangbian capsule

ObjectiveTo study the effects of Zhiwei Fangbian Capsule (ZWFBC) on lactic dehydrogenase (LDH), succinic dehydrogenase (SDH) and ATPase activities in gastric mucosa of chronic atrophic gastritis (CAG) rats with Qi deficiency and blood stasis syndrome.MethodsTotally 90 rats were randomly divided into 2 groups: normal group (n=10) and model group (n=80). The CAG rat model of Qi deficiency and blood stasis type was induced by synthetic methods. After modeling for 12 weeks and the successful CAG model was determined, the CAG model rats were divided by random number table into model group (MG), ZWFB high-dose group (ZWFBH), ZWFB middle-dose group (ZWFBM), ZWFB low-dose group (ZWFBL) and Weimeisu group (WM), 9 rats in each group. The rats in the normal and model groups were intragastrically administrated with distilled water, 10 mL/kg every day; the ZWFB high-dose group with ZWFB, 0.6 g·kg−1·d−1; the ZWFB middle-dose group with ZWFB, 0.3 g·kg−1·d−1; the ZWFB low-dose group with ZWFB, 0.15 g·kg−1·d−1, and the WM group with suspension of WM, 0.25 g·kg−1·d−1 . The treatment was given for 90 consecutive days. Then general survival states were observed and the activities of lactic dehydrogenase (LDH), succinic dehydrogenase (SDH), Na+-K+-ATPase and Ca2+-Mg2+-ATPase in gastric mucosa tissue were detected.ResultsCompared with the normal group, activity of LDH in the gastric mucosa (P<0.05) and activities of SDH, Na+-K+-ATPase and Ca2+-Mg2+-ATPase significantly decreased in the normal group (P<0.05). Compared with the model group the activity of LDH decreased and activities of SDH, Na+-K+-ATPase and Ca2+-Mg2+-ATPase significantly increased in the high dose ZWFB group (P<0.05).ConclusionZWFB Capsule can promote energy metabolism and ATPase activity in the gastric mucosa cell, so as to protect the function of the gastric mucosa cell.