کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4209949 | 1609419 | 2006 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A brief history of inhaled asthma therapy over the last fifty years
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی ریوی و تنفسی
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چکیده انگلیسی
This year is the 50th anniversary of the introduction into clinical use of the first modern inhaler for the management of asthma - the pressurised metered-dose inhaler (pMDI). The pMDI was initially used for the administration of the non-selective beta-agonists adrenaline and isoprenaline. However, the epidemic of asthma deaths which occurred in the 1960s led to these drugs being superseded by the selective short-acting beta-agonist salbutamol, and the first inhaled corticosteroid (ICS) beclomethasone. At the same time, sodium cromoglycate was introduced, to be administered via the first dry-powder inhaler - the Spinhaler - but owing to its relatively weak anti-inflammatory action its use is now very limited. Over the last 10 years, the long-acting beta-agonists (LABAs) have become an important add-on therapy for the management of asthma, and they are now often used with ICS in a single ICS/LABA combination inhaler.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Primary Care Respiratory Journal - Volume 15, Issue 6, December 2006, Pages 326-331
Journal: Primary Care Respiratory Journal - Volume 15, Issue 6, December 2006, Pages 326-331
نویسندگان
Graham Crompton,