کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4210482 | 1280593 | 2013 | 9 صفحه PDF | دانلود رایگان |

BackgroundAsthma has been linked to obesity and the presence of the metabolic syndrome.Objective: To explore which components of the metabolic syndrome that were associated with wheezing, a main symptom of asthma. Further, to explore whether these associations were different in individuals with and without rhinitis symptoms.MethodsWe used data from the Ibermutuamur Cardiovascular Risk Assessment Plan (ICARIA) including 85,555 Spanish workers (median age = 34, range = 16–75 years) with assessments of self reported wheezing and rhinitis symptoms. Fasting blood samples were analysed for serum triglyceride (s-TG), HDL (s-HDL) and glucose; blood pressure, waist circumference (WC) and body mass index (BMI) were measured.ResultsIn mutually adjusted analyses including all components of the metabolic syndrome and possible confounders, elevated WC (or BMI), elevated s-TG and low s-HDL were significantly associated with wheezing. Odds ratio (OR) with confidence interval (CI) were: elevated WC = 1.54 (1.46–1.62), elevated s-TG = 1.24 (1.18–1.30), low s-HDL = 1.17 (1.12–1.22). These associations were stronger in individuals without than in those with rhinitis symptoms, OR's (CI's) were WC = without rhinitis 1.70 (1.57–1.85) vs. with rhinitis 1.47 (1.37–1.58). Elevated s-TG = without rhinitis 1.36 (1.26–1.46) vs. with rhinitis 1.21 (1.13–1.29). Low s-HDL = without rhinitis 1.24 (1.15–1.34) vs. with rhinitis 1.11 (1.04–1.18).ConclusionsHigh s-TG and low s-HDL were associated with wheezing after adjustment for adiposity. This may substantiate elevated s-TG and lowered s-HDL as markers or inducers of inflammation associated disease. The study supports the notion that these biochemical markers have differential effects on different types of wheezing.
Journal: Respiratory Medicine - Volume 107, Issue 6, June 2013, Pages 816–824