کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4210525 | 1280594 | 2010 | 6 صفحه PDF | دانلود رایگان |
SummaryBackgroundReduced arterial elasticity is an important mediator of accelerated atherogenesis and consequent increased cardiovascular morbidity in obstructive sleep apnea (OSA). The aim of our study was to investigate whether continuous positive airway pressure (CPAP) therapy may improve arterial elasticity in subjects with OSA.MethodsIn 44 subjects with OSA, we measured arterial elasticity by applanation tonometry before and after 6 months of treatment with CPAP. Nine OSA+ subjects withdrew from the study.ResultsThe 35 patients with OSA who completed the 6-month CPAP treatment showed a marked reduction in both the large artery (LAEI, P = 0.001) and small artery (SAEI, P = 0.009) elasticity indices, independent of potential confounders. In OSA+ subjects who withdrew from the study, SAEI and LAEI did not change significantly over time.ConclusionsSix months of CPAP therapy improves arterial elasticity in subjects with OSA.
Journal: Respiratory Medicine - Volume 104, Issue 10, October 2010, Pages 1571–1576