کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4210543 | 1280596 | 2012 | 9 صفحه PDF | دانلود رایگان |
SummaryBackgroundLymphangioleiomyomatosis (LAM) is characterised by progressive airway obstruction and hypoxaemia in young women. Although sleep may trigger hypoxaemia in patients with airway obstruction, it has not been previously investigated in patients with LAM.MethodsConsecutive women with lung biopsy proven LAM and absence of hypoxaemia while awake were evaluated with pulmonary function test, echocardiography, 6-min walk test, overnight full polysomnography, and Short Form 36 health-related quality-of-life questionnaire.ResultsTwenty-five patients with (mean ± SD) age 45 ± 10 years, SpO2 awake 95% ± 2, forced expiratory volume in the first second (median–interquartile) FEV1(% predicted) 77 (47–90) and carbonic monoxide diffusion capacity, DLCO (%) 55 (34–74) were evaluated. Six-minute walk test distance and minimum SpO2 (median–interquartile) were, respectively, 447 m (411–503) and 90% (82–94). Median–interquartile apnoea–hypopnoea index was in the normal range 2 (1–5). Fourteen patients (56%) had nocturnal hypoxaemia (10% total sleep time with SpO2 <90%), and the median sleep time spent with SpO2 <90% was 136 (13–201) min. Sleep time spent with SpO2 <90% correlated with the residual volume/total lung capacity ratio (rs = 0.5, p: 0.02), DLCO (rs = −0.7, p: 0.001), FEV1 (rs = −0.6, p: 0.002). Multivariate linear regression model showed that RV/TLC ratio was the most important functional variable related to sleep hypoxaemia.ConclusionSignificant hypoxaemia during sleep is common in LAM patients with normal SpO2 while awake, especially among those with some degree of hyperinflation in lung function tests.
Journal: Respiratory Medicine - Volume 106, Issue 3, March 2012, Pages 420–428