کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4210555 1280597 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A single dose of Sildenafil does not enhance FeNO: A randomised, cross-over and placebo-controlled study
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی ریوی و تنفسی
پیش نمایش صفحه اول مقاله
A single dose of Sildenafil does not enhance FeNO: A randomised, cross-over and placebo-controlled study
چکیده انگلیسی

SummaryMonitoring of asthma control can be performed with different means including measurement of the concentration of nitric oxide (NO) in exhaled air. Due to its action on the NO-metabolism; we hypothesized that the intake of Sildenafil might augment and falsify the NO-values in exhaled air of subjects taking the drug to treat erectile dysfunction.This randomised, placebo-controlled cross-over study including 10 male non-asthmatic volunteers taking a single dose of 50 mg Sildenafil did not confirm this assumption in non-asthmatic subjects. We cannot think of any reason why asthmatics should behave differently.On the basis of these results, it does not seem necessary to ask asthma patients with elevated NO-values if they had taken any selective inhibitor of the cGMP-specific phosphodiesterase Type 5 as Sildenafil prior to the test.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Medicine - Volume 104, Issue 6, June 2010, Pages 788–793
نویسندگان
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