کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4211138 1280626 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Association between serum neopterin, obesity and daytime sleepiness in patients with obstructive sleep apnea
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی ریوی و تنفسی
پیش نمایش صفحه اول مقاله
Association between serum neopterin, obesity and daytime sleepiness in patients with obstructive sleep apnea
چکیده انگلیسی

SummaryObjectiveObesity and obstructive sleep apnea (OSA) and systemic inflammation may interact through biochemical pathways. Neopterin (NP) is a monocyte/macrophage activation marker produced by macrophages in response to interferon-gamma secreted by activated T-lymphocytes. This study examines the association between NP, obesity and OSA.Patients and methodsThe study included 22 newly diagnosed OSA (+) patients and 18 OSA (−) patients. Subjects with history of coronary artery disease, transplant patients, history of alcohol and drug abuse, history of HIV and any other significant medical illnesses such as active infections, autoimmune disease, malignancy, liver disease, pulmonary disease (COPD, asthma,…), neuromuscular disease, patients on immunomodulating therapy or HMG-CoA reductase inhibitors were excluded.ResultsThere were no significant differences in age, body mass index (BMI), and smoking habits of the OSA (+) patients and OSA (−) patients. Serum NP levels did not show any significant difference between the OSA (+) patients and OSA (−) patients, however, NP levels were positively correlated with BMI (r = 0.320, p = 0.044). There was no significant correlation between NP and any of the polysomnographic parameters. The result of stepwise regression analyses (r2 = 0.320, p < 0.001) showed that high serum NP levels (p = 0.004) and apnea–hypopnea index (AHI) were a risk factor for elevated Epworth sleepiness score, independent of BMI.ConclusionWe suggest that serum NP levels correlate with BMI. There was a significant relationship between serum NP levels and excessive daytime sleepiness in OSA patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Medicine - Volume 102, Issue 8, August 2008, Pages 1193–1197
نویسندگان
, , , , , ,