کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4211230 1280630 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Increased oral nitric oxide in obstructive sleep apnoea
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی ریوی و تنفسی
پیش نمایش صفحه اول مقاله
Increased oral nitric oxide in obstructive sleep apnoea
چکیده انگلیسی

SummaryBackgroundHypoxia and snoring-related mechanical trauma contribute to airway inflammation in obstructive sleep apnoea (OSA). Increased exhaled nitric oxide (FENO), an airway inflammation marker, has been reported in OSA patients. We propose the measure of NO in the oral cavity (oNO) as marker of oropharyngeal inflammation in OSA.MethodsWe compared oNO and FENO of 39 OSA patients with those of 26 mild asthmatics (ASTHMA), 15 patients with chronic rhinitis or rhinosinusitis (CRS) and 24 healthy subjects. A special device was used for oNO measurement. Apnoea/hypopnoea index (AHI), oxygen desaturation index, mean and nadir SaO2 were calculated from the polysomnography.ResultsoNO was significantly increased in OSA (104.2 95%CI 80.2–135.5 ppb) as compared to ASTHMA (71.9 95%CI 56.3–91.9 ppb; p = 0.015), CRS (54.4 95%CI 40.2–73.7 ppb; p = 0.009) and healthy subjects (63.6 95%CI 59–73 ppb; p < 0.001). oNO was directly related to AHI (r = 0.466, p = 0.003) and to minutes slept with SaO2 <90% (r = 0.471, p = 0.011) and it was inversely related to nadirSaO2 (r = −0.393, p = 0.018). FENO was highest in asthmatics (40.3 95%CI 32.5–50.1 ppb) and only slightly elevated in OSA (23.1 95%CI 19,8–28.3 ppb) and CRS (22.8 95%CI 16.8–32.5 ppb).ConclusionsThe finding that oral NO is increased in OSA and is related to upper airway obstructive episodes and to hypoxemia severity, strengthens the clinical and pathogenic role of oral inflammation in OSA.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Medicine - Volume 104, Issue 2, February 2010, Pages 316–320
نویسندگان
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