کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4211277 1280632 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Suppressed signal transduction in the bronchial epithelium of patients with systemic sclerosis
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی ریوی و تنفسی
پیش نمایش صفحه اول مقاله
Suppressed signal transduction in the bronchial epithelium of patients with systemic sclerosis
چکیده انگلیسی

SummaryIntroductionSystemic sclerosis (SSc) is an autoimmune disorder, which frequently affects the lungs, with manifestations of interstitial lung disease (ILD) with lung fibrosis and of pulmonary hypertension. The pathogenesis remains largely unrecognised.ObjectiveThe aim of this study was to elucidate the inflammation in the bronchial mucosa in patients with SSc.Subjects and methodsTwenty-three subjects diagnosed with SSc participated. Twelve of the SSc patients showed signs of ILD, four were smokers and seven were treated with oral corticosteroids. Seventeen non-smoking, age- and sex-matched healthy subjects served as controls. Bronchoscopy was performed to sample endobronchial mucosal biopsies, which were immunohistochemically stained using a panel of antibodies against inflammatory markers.ResultsThe number of neutrophils was significantly elevated in the submucosa of SSc patients, regardless of ILD, or whether the subject was smoking or using oral corticosteroids. No up-regulation of neutrophil chemoattractants or cytokines was seen in the bronchial epithelium. The signal transduction pathways and adhesion molecule expression tended to be suppressed or unchanged in SSc patients compared with controls.ConclusionIt is concluded that SSc is associated with a chronic neutrophilic inflammation in the bronchial mucosal, with signs of suppressed signal transduction, regardless of the presence of interstitial lung disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Medicine - Volume 103, Issue 2, February 2009, Pages 301–308
نویسندگان
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