کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4211476 1280642 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Inhaled colistin as monotherapy for multidrug-resistant gram (−) nosocomial pneumonia: A case series
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی ریوی و تنفسی
پیش نمایش صفحه اول مقاله
Inhaled colistin as monotherapy for multidrug-resistant gram (−) nosocomial pneumonia: A case series
چکیده انگلیسی

SummaryBackgroundReports of patients with polymyxin-only susceptible gram-negative nosocomial pneumonia treated with inhaled, but without concurrent intravenous, colistin are rare.MethodsPatients admitted in a tertiary 450-bed tertiary care centre during the period 05/01/2005–05/31/2007 and receiving colistin through nebulization, but not systemically, were included in this retrospective case series.ResultsFive patients (three with ventilator-associated pneumonia and two with nosocomial pneumonia) received colistin through nebulization without concomitant intravenous colistin. The isolated pathogens were Acinetobacter baumannii (three cases), Pseudomonas aeruginosa (one case) and the combination of Klebsiella pneumoniae, A. baumannii and P. aeruginosa (one case). They were susceptible only to colistin (three cases) or to colistin and gentamicin (two cases). Intravenous antimicrobial agents given concurrently were piperacillin/tazobactam, meropenem, ceftriaxone and ciprofloxacin; isolated pathogens were resistant to these agents. Four (80%) out of the five patients were cured, survived and were discharged. One patient died. No colistin-related adverse event was observed.ConclusionsThe experience from this case series and other relevant recent reports suggest that treatment of pneumonia due to polymyxin-only susceptible gram-negative bacilli with inhaled colistin (without concurrent systemic administration) deserves further careful investigation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Medicine - Volume 103, Issue 5, May 2009, Pages 707–713
نویسندگان
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