کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4211675 1280648 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Exacerbations and lung function decline in COPD: New insights in current and ex-smokers
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی ریوی و تنفسی
پیش نمایش صفحه اول مقاله
Exacerbations and lung function decline in COPD: New insights in current and ex-smokers
چکیده انگلیسی

SummaryAimTo investigate whether there is a significant relationship between an increased frequency of exacerbations and the rate of forced expiratory volume in 1 s (FEV1) decline in COPD patients.Methods–measurementsAbout 102 COPD patients (44 smokers, 58 ex-smokers) participated in a 3-year prospective study. Exacerbations were identified as worsening of patient's respiratory symptoms as recorded on diary cards. Spirometry was performed every 6 months. The effect of frequent exacerbations on lung function was investigated using random effects models.ResultsThe median (mean(95% CI)) annual exacerbation rate was 2.85 (3.1 (2.7–3.6)). Patients with an annual exacerbation rate over the median rate had significantly lower baseline post-bronchodilation FEV1(%pred), higher MRC dyspnoea score and chronic cough compared to patients who had an annual exacerbation rate less than the median. The average annual rate of FEV1(%pred), adjusted for smoking decline (ΔFEV1), was found significantly increased in frequent compared to infrequent exacerbators (P=0.017P=0.017). The highest ΔFEV1 was observed in smokers frequent exacerbators and a significant interaction between exacerbation frequency and ΔFEV1 was also observed in ex-smokers.ConclusionsOur findings suggest that an increased frequency of exacerbations is significantly associated with FEV1 decline even in ex-smokers. Thus, smoking and frequent exacerbations may have both negative impact on lung function. Smoking cessation and prevention of exacerbations should be a major target in COPD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Medicine - Volume 101, Issue 6, June 2007, Pages 1305–1312
نویسندگان
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