The short-term administration of Ketoprofen does not decrease the effect of Pleurodesis induced by talc or Doxycycline in rabbits

SummaryObjective: To determine whether the concomitant administration of ketoprofen, a non-steroidal anti-inflammatory drug (NSAID) has any effect on the pleurodesis induced by talc or doxycycline in rabbits.Methods: Four groups of seven New Zealand rabbits were assigned to receive the following treatments: 400 mg/kg of talc intrapleurally only (group 1), 400 mg/kg of talc plus 1 mg/kg of ketoprofen intramuscularly (group 2), 10 mg/kg of doxycycline intrapleurally only (group 3) and 10 mg/kg of doxycycline plus 1 mg/kg of ketoprofen intramuscularly (group 4). Intramuscular administration of ketoprofen began 4 h before the intrapleural administration of the sclerosing agents, followed by twice daily administrations for 1 week. Pleural fluid was collected 24, 48 and 72 h after intrapleural injections. Pleurodesis was evaluated macroscopically and microscopically after 14 days.Results: The concomitant use of ketoprofen at 1 mg/kg does not decrease the WBC, LDH, and protein in pleural fluid at 24 h following intrapleural injection of talc or doxycycline. There were no significant differences in the macroscopic pleurodesis scores, the degree of microscopic pleural fibrosis, the thickness of the pleura or the percent of the pleura occupied with angiogenesis.Conclusions: The study shows that the short-term systemic administration of NSAIDs does not affect the efficacy of pleurodesis induced by talc or doxycycline in rabbits.