کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4212106 1280664 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Racial and gender differences in susceptibility to tobacco smoke among patients with chronic obstructive pulmonary disease
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی ریوی و تنفسی
پیش نمایش صفحه اول مقاله
Racial and gender differences in susceptibility to tobacco smoke among patients with chronic obstructive pulmonary disease
چکیده انگلیسی

SummaryBackgroundAlthough chronic obstructive pulmonary disease (COPD) has been considered a disease of Caucasian men, recent data show mortality rising faster among women and African-Americans. Some have suggested these groups are more susceptible to tobacco smoke. We examined this issue in our own population of COPD patients.MethodsBeginning in March 2003 we prospectively developed a COPD research database to facilitate recruitment for clinical trials. Enrollees are recruited from clinics and paid advertising and their demographics, medical/smoking histories, and spirometric data are recorded. We examined the smoking histories and pulmonary function of enrollees over 45, with ⩾20 pack-years of smoking, FEV1/FVC (forced expiratory volume forced vital capacity) <0.70, and a race-adjusted post-bronchodilator FEV1<80%. The primary outcome was the loss of lung function per pack-year smoked, or Susceptibility Index (SI), calculated using the formula: (% predicted FEV1−100)/pack-years.ResultsA total of 585 patients enrolled during the study period and 330 met our inclusion criteria. Caucasians were older than African-Americans (63 vs. 58, P=0.0003P=0.0003) and had more pack-years of smoking (57 vs. 43, P=0.0003P=0.0003). There were no differences in lung function or bronchodilator reversibility among the racial or gender subgroups. Caucasians had less loss of lung function per pack-year smoked than African-Americans (SI=-1.02%SI=-1.02% vs. −1.34%, P=0.007P=0.007) and men less than women (SI=-0.98%SI=-0.98% vs. −1.21%, P=0.001P=0.001). Caucasian males appeared relatively protected from tobacco smoke (SI=-0.93%SI=-0.93%), while African-American women appeared most susceptible (SI=-1.42%SI=-1.42%).ConclusionsThere are important differences in racial and gender susceptibility to tobacco smoke among patients with COPD. African-American females appear to be at highest risk and may benefit most from smoking cessation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Medicine - Volume 100, Issue 6, June 2006, Pages 1110–1116
نویسندگان
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