کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4212259 1280673 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Control of mild to moderate asthma over 1-year with the combination of salmeterol and fluticasone propionate
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی ریوی و تنفسی
پیش نمایش صفحه اول مقاله
Control of mild to moderate asthma over 1-year with the combination of salmeterol and fluticasone propionate
چکیده انگلیسی

SummaryObjectiveThe aim of this study was to assess asthma control using salmeterol plus fluticasone propionate (FP) in combination (SFC) versus salmeterol or FP as monotherapy in patients with mild to moderate asthma.MethodsIn this randomised, double-blind, parallel-group study, 322 symptomatic patients were recruited, of which 282 were randomised to receive either salmeterol (50 μg), FP (250 μg), or SFC (50 μg/250 μg), via a single Diskus™ inhaler twice daily for 12 months. Outcome variables included the number of patients requiring an increase in study medication and the number experiencing ⩾2 exacerbations during the 12-month treatment period. Airway hyper-responsiveness (AHR) and lung function tests were performed at clinic visits. Peak expiratory flow, rescue medication use, symptom scores and adverse events were recorded in diary cards.ResultsFewer patients required an increase in study medication with SFC (10.5%) than with either FP (34.8%) or salmeterol (61.1%) (P<0.001). Significantly fewer patients experienced ⩾2 exacerbations with SFC (4.2%), compared with FP (17.4%; P<0.01) or salmeterol (40%; P<0.001). SFC improved AHR to a significantly greater extent than FP (methacholine PC20=1.8 mg/ml vs. 1.1 mg/ml; P<0.05) or salmeterol (methacholine PC20=1.8 mg/ml vs. 0.7 mg/ml; P<0.001).ConclusionsThe protection against exacerbations may be attributed to better control of inflammation, AHR and lung function parameters achieved with salmeterol and FP in combination, compared with either treatment alone.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Medicine - Volume 100, Issue 1, January 2006, Pages 2–10
نویسندگان
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