Aspergillus-related lung disease

SummaryAspergilli are ubiquitous fungi with branched septate hyphae. Aspergillus produces a wide variety of diseases determined by the inoculating dosage, the ability of the host to resist infection at local and systemic levels and the virulence of the organism. These entities differ clinically, radiologically, immunologically, and in their response to various therapeutic agents. Although the fungus can affect any organ system, the respiratory tract is involved in >90% of affected patients. A broad knowledge is required to timely diagnose and aggressively treat the potentially lethal manifestations of Aspergillus-related pulmonary diseases.