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In elderly patients, Performance status is unable to summarize their clinical status and especially the ability to receive chemotherapy. Other factors which are part of a comprehensive geriatric assessment are to be taken into account such as the activity Daily Living or the Instrumental Activity Daily Living scores but also the Mini Mental Status, the Timed up and go, comorbities rating, depression and nutritional evaluation. This comprehensive geriatric assessment is (CGA) time consuming and some screening scores were developed in order to select those patients who really need this CGA. After geriatric assessment, elderly patients will be classified in one of the three Balducci groups with according to the group, a proposal of a very similar treatment to that of younger counterparts or an adapted treatment or to best supportive care only. If the prognostic role of some of the geriatric scores is well-established, their predictive role still needs to be studied.