Is primary tumor detectable in prostatic carcinoma at routine contrast-enhanced CT?

ObjectivesTo determine if prostatic carcinoma (PCa) is detectable at routine contrast-enhanced CT (CECT).Materials and MethodsWith institutional review board approval, 63 consecutive PCa patients underwent CECT before therapy. Two blinded radiologists assessed for rounded focal enhancing peripheral zone nodules. Diagnostic accuracy and inter-observer agreement were compared by Gleason Score (GS).ResultsOverall sensitivity was 63–76% with moderate agreement, K= 0.42. The false-positive rate was 15%. Sensitivities and agreement for GS 9–10, 7–8 and 6 PCa were 84–91%, 73–84%, 41–71%, (P= .023 and .001) and K=(0.72, 0.69, 0.23).ConclusionsCECT has good sensitivity for detecting GS ≥ 7 PCa with substantial agreement and a low false-positive rate.