Optimal cut-off value of perfusion parameters for diagnosing prostate cancer and for assessing aggressiveness associated with Gleason score

To determine cut-off value of dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) parameters for differentiation of prostate malignant from benign and cancer with high-grade Gleason score (GS) (GS>7) from low-grade GS (GS≤7), 35 patients (24 malignant and 11 benign) who underwent DCE-MRI were included. Difference between malignant and benign was statistically significant for all magnetic resonance parameters except Ve. The cut-off values were Ktrans= 0.184 min− 1, Kep= 0.695 min− 1, iAUC=4.219 mmol/l/min, and ADC=1340.5 mm2/s. A significant difference in mean values of Ktrans and Kep between cancer with high-grade GS and low-grade GS was also observed. Ktrans and Kep showed a significant correlation with GS.