Seminal megavesicle in autosomal dominant polycystic kidney disease

Retrospective analysis of 99 male autosomal dominant polycystic kidney disease (ADPKD) patients compared to an age-matched control population showed seminal vesicle ectasia > 10 mm (megavesicle) in 23% (23/99) of ADPKD patients that was not present in any controls (P< .0001). Median (range) seminal vesicle convoluted tubule diameter in ADPKD patients was 4.2 (1.7–30) mm compared to 3.1 (1.7–6.8) mm in controls (P< .0001). Discrete cysts were identified in four ADPKD patients but in none of the control population (P= .12). Seminal megavesicles may explain the infertility sometimes observed in male ADPKD patients.