Sulfonic acid supported on hydroxyapatite-encapsulated-γ-Fe2O3 nanocrystallites as a magnetically Brønsted acid for N-formylation of amines

Treatment of aqueous formic acid (85%) with structurally diverse amines in the presence of a catalytic amount of sulfonic acid supported on hydroxyapatite-encapsulated-γ-Fe2O3 [HAp@-γ-Fe2O3] (0.9 mol.%) as a heterogeneous, reusable and highly efficient catalyst gave the corresponding formamides in good to excellent yields at room temperature. The magnetically catalytic system was recovered by-passing time consuming filtration operation by using an external magnet device. In addition to facility, this methodology, it also enhances product purity and promises economic as well as environmental benefits.

Treatment of aqueous formic acid with structurally diverse amines in the presence of a catalytic amount of sulfonic acid supported on HAp-encapsulated-γ-Fe2O3 as a heterogeneous, reusable and highly efficient catalyst gave the corresponding formamides. The magnetically catalytic system was recovered by-passing time consuming filtration operation by using an external magnet device.Figure optionsDownload high-quality image (45 K)Download as PowerPoint slide