Zr(HSO4)4 and Mg(HSO4)2 as mild and efficient catalysts for the one-pot multicomponent synthesis of β-acetamido carbonyl compounds

Synthesis of β-acetamido carbonyl compounds by the one-pot multicomponent coupling of an aromatic aldehyde, an enolisable ketone or keto ester, acetonitrile, and acetyl chloride using Zr(HSO4)4 and Mg(HSO4)2 as mild, inexpensive, and highly efficient catalysts is studied in the present article.

An efficient one-pot three-component coupling process for the synthesis of β-acetamido ketones or esters catalyzed by Zr(HSO4)4 and Mg(HSO4)2 at room temperature has been described. The mechanism of this reaction was also studied. The present methodology offers several advantages such as excellent yield, simple procedure, short reaction time and milder conditions.Figure optionsDownload as PowerPoint slide