Primary endometrial B-Cell lymphoma: Rare etiology of abnormal uterine bleeding and potential nonsurgical therapy

We present a case of primary endometrial B-cell lymphoma, pathologically confirmed. The patient is a 68-year-old female with postmenopausal bleeding. Ultrasound revealed endometrial thickening and was followed up with endometrial biopsy. F18-FDG PET, performed for staging, demonstrated abnormally increased radiotracer uptake isolated to the endometrium. The patient was treated with chemotherapy (R-CHOP) and external-beam radiation. Endometrial activity was resolved on post-treatment followup F18-FDG PET. Primary endometrial lymphoid neoplasms are extremely rare (approximately 2% of extranodal lymphoid neoplasms); even rarer is primary B-cell lymphoma. To our knowledge, this is the first reported case of a successful treatment of endometrial lymphoma using external-beam radiation and chemotherapy in a patient who did not receive hysterectomy.