Can vacuum morphologies predict solubility and intrinsic dissolution rate? A case study with felodipine polymorph form IV

• The impact of felodipine (Fel) polymorphism on vacuum morphology was studied.
• A correlation was established between solubility and IDR of three Fel polymorphs.
• Rank order correlation of II > I/IV > III was obtained for solubility and IDR.
• Such study would broaden information related to face-specific properties of drugs.

The impact of felodipine (Fel) polymorphism on vacuum morphology was studied and correlated with the structural properties like solubility and intrinsic dissolution rate (IDR). A correlation was established between solubility and IDR of three Fel polymorphs with their BFDH aspect ratio, growth morphology aspect ratio and polar/non polar ratio. The predicted solubility and IDR values for form IV by three methods were in agreement, however, morphology growth aspect ratio model showed better prediction capability due to its higher coefficient of determination. The solubility for form IV was 0.0154 mol l−1 while the IDR was 0.246 mg min−1 cm−2 for growth morphology aspect ratio.