کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4312031 1612918 2016 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Altered consolidation of extinction-like inhibitory learning in genotype-specific dysfunctional coping fostered by chronic stress in mice
ترجمه فارسی عنوان
تحکیم تغییر یافته از یادگیری مهار کننده انقراض مانند مقابله با اختلالات عملکردی ویژه ژنوتیپ که از استرس مزمن در موش ها حاصل می شود
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی


• Food restricted C57BL/6J mice show enhanced and DBA/2J mice show reduced infralimbic c-fos induction by acute stress.
• The Infralimbic Cortex is involved in consolidation of an acquired coping strategy in both mouse strains.
• Food restricted C57BL/6J mice show enhanced and DBA/2J mice show reduced retention of escape extinction.

Genetic and stress-related factors interact to foster mental disorders, possibly through dysfunctional learning. In a previous study we reported that a temporary experience of reduced food availability increases forced swim (FS)-induced helplessness tested 14 days after a first experience in mice of the standard inbred C57BL/6(B6) strain but reduces it in mice of the genetically unrelated DBA/2J (D2) strain. Because persistence of FS-induced helplessness influences adaptive coping with stress challenge and involve learning processes the present study tested whether the behavioral effects of restricted feeding involved altered consolidation of FS-related learning.First, we demonstrated that restricted feeding does not influence behavior expressed on the first FS experience, supporting a specific effect on persistence rather then development of helplessness. Second, we found that FS-induced c-fos expression in the infralimbic cortex (IL) was selectively enhanced in food-restricted (FR) B6 mice and reduced in FR D2 mice, supporting opposite alterations of consolidation processes involving this brain area. Third, we demonstrated that immediate post-FS inactivation of IL prevents 24 h retention of acquired helplessness by continuously free-fed mice of both strains, indicating the requirement of a functioning IL for consolidation of FS-related learning in either mouse strain. Finally, in line with the known role of IL in consolidation of extinction memories, we found that restricted feeding selectively facilitated 24 h retention of an acquired extinction in B6 mice whereas impairing it in D2 mice.These findings support the conclusion that an experience of reduced food availability strain-specifically affects persistence of newly acquired passive coping strategies by altering consolidation of extinction-like inhibitory learning.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research SreeTestContent1 SreeTestContent1 - Volume 315, 15 December 2016, Pages 23–35
نویسندگان
, , , ,