Not all stress is equal: CREB is not necessary for restraint stress reinstatement of cocaine-conditioned reward

► Fifteen-minute restraint stress can elicit reinstatement of cocaine-conditioned reward. ► Unlike swim stress, CREB is not necessary for restraint-induced reinstatement of cocaine CPP. ► CREB is necessary for swim-stress-elicited zif268 expression. ► CREB is not necessary for restraint-stress-elicited zif268 expression.