Medial prefrontal cortex lesions impair decision-making on a rodent gambling task: Reversal by D1 receptor antagonist administration

► Lesions of the medial prefrontal cortex impaired stable decision-making. ► The D1 receptor antagonist SCH23390 reversed the lesion-induced decision-making deficit. ► The D2-like receptor antagonist haloperidol did not affect decision-making.