کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4312778 | 1612989 | 2013 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Ethanol-induced conditioned partner preference in female mice Ethanol-induced conditioned partner preference in female mice](/preview/png/4312778.png)
Drinking behavior and social context are intimately intertwined. Peer relations can promote drinking. Conversely, alcohol promotes social interaction. The present study tested female mice for ethanol-induced conditioned partner preference. Ovariectomized (OVX) C57Bl/6 females with chronic estradiol replacement (OVX+E) received saline or ethanol (1, 2 or 4 g/kg) ip and were paired 4× for 30 min each with 1 of 2 stimulus females. The test female was paired with the CS− stimulus female following saline, and was paired with the CS+ female following ethanol. After pairing, we measured proximity of the test female to the CS+ and CS− females in a 10’ test. In a second study, OVX and OVX+E females were tested for conditioned partner preference (CS+ vs. CS−) in response to 2.5 g/kg ethanol. In separate groups of mice, both test and stimulus females (IS+) received ethanol during pairing to determine if test mice develop conditioned partner preference for another intoxicated mouse. OVX+E test females showed conditioned partner preference for the CS+ female in response to ethanol at 2 g/kg (change in preference score for CS+: +86.6 ± 30.0 s/10 min), but not at 0, 1 or 4 g/kg. At 2.5 g/kg ethanol, OVX+E females developed conditioned partner preference for either IS+ (+63.6 ± 24.0 s) or CS+ females (+93.8 ± 27.1 s). OVX test females demonstrated ethanol-induced conditioned partner preference only for the IS+ female (+153.8 ± 32.0 s). These data demonstrate that ethanol promotes social preference in female mice, and that estradiol enhances this effect.
► We tested effects of ethanol on conditioned partner preference in female mice to explore social dimensions of substance abuse.
► Test females showed a conditioned preference for a stimulus female (CS+) paired with ethanol.
► Conditioned partner preference was maintained if the CS+ female was also intoxicated.
► Estrogen replacement in ovariectomized females facilitated ethanol-induced conditioned partner preference.
Journal: Behavioural Brain Research - Volume 243, 15 April 2013, Pages 273–277