کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4313097 1289985 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
GABAergic processes within the median preoptic nucleus promote NREM sleep
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
GABAergic processes within the median preoptic nucleus promote NREM sleep
چکیده انگلیسی

GABAergic mechanisms in the preoptic region of the hypothalamus (POA) have been implicated in the generation and maintenance of NREM (quiet) sleep. We recently reported that neurons in the median peptic nucleus (MnPN) in the POA of the cat are selectively activated during NREM sleep. In the present study, we explored the hypothesis that NREM sleep is controlled by GABAergic mechanisms within the MnPN. Consequently, adult cats were utilized to determine GABA immunorreactivity within the MnPN and to examine the effects on sleep of the microinjection of a GABAA agonist (muscimol) and a GABAA antagonist (bicuculline) into this area.GABAergic neurons were present throughout the MnPN. Compared with control microinjections, after the application of muscimol, the time spent in NREM sleep (59.8 ± 7.5 min) and REM sleep (6.9 ± 4.7 min) decreased compared with control microinjections (103.8 ± 5.2 and 20.2 ± 4.3 min, respectively; P < 0.005). In contrast, bicuculline microinjections increased only NREM sleep time (103.0 ± 23.0 vs 77.7 ± 23.7 min; P < 0.05).These results demonstrate that GABAergic processes within the MnPN are involved in the generation and maintenance of sleep, especially NREM sleep.


► GABAergic neurons are present within the MnPN of the cat.
► Microinjection of muscimol into the MnPN of the cat induces wakefulness.
► Microinjection of bicuculline into the MnPN of the cat promotes sleep.
► The MnPN is involved in the generation of sleep.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 232, Issue 1, 15 June 2012, Pages 60–65
نویسندگان
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