کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4313122 | 1289985 | 2012 | 9 صفحه PDF | دانلود رایگان |
This study examined the effects of the bacterial endotoxin, lipopolysaccharide (LPS), on the establishment of anticipatory nausea and conditioned taste avoidance in a simultaneous conditioning paradigm using an intravascular/intraperitoneal saccharin taste. 83 naïve adult male Long-Evans rats were injected (intraperitoneal) with either 200 μg/kg LPS or 0.9% saline (NaCl), 90 min prior to ip treatment with either 64 mg/kg LiCl, 64 mg/kg LiCl + 2.0% saccharin, 0.9% NaCl, or 0.9% NaCl + 2.0% saccharin, and immediately placed into a distinctive context for 30 min (repeated over 4 conditioning days, spaced 72 h apart). 72 h following the final conditioning day, each animal was re-exposed to the context on a drug-free test day where orofacial responding was recorded. The next day, animals received a 24 h 2-bottle preference test with a choice between water and a palatable 0.2% saccharin solution. Results showed that LPS exposure, prior to LiCl or LiCl + Saccharin treatment, inhibited the establishment of anticipatory nausea, as evidenced by significantly lower conditioned gaping frequencies relative to animals pre-treated with NaCl followed by LiCl or LiCl + Saccharin. LPS pre-treatment also inhibited the formation of LiCl-induced taste avoidance, as evidence by significantly higher saccharin preferences in Group LPS–LiCl + Saccharin relative to Group NaCl–LiCl + Saccharin. The results of the current study provide additional evidence for the deleterious effects of LPS on learning and memory in aversive conditioning.
► Immune system stimulation impairs anticipatory nausea and conditioned taste avoidance.
► LPS inhibits LiCl-induced conditioned gaping.
► LPS inhibits LiCl-induced intravascularly conditioned taste avoidance.
► LPS produced robust initial weight loss relative to NaCl pre-treated animals.
► LPS disrupts learning and memory in a simultaneous aversive conditioning paradigm.
Journal: Behavioural Brain Research - Volume 232, Issue 1, 15 June 2012, Pages 278–286