Improved motor performance in Dyt1 ΔGAG heterozygous knock-in mice by cerebellar Purkinje-cell specific Dyt1 conditional knocking-out

► Enhanced motor coordination in Purkinje cell-specific Dyt1 conditional knockout mice. ► Motor deficits rescue in Dyt1 knock-in mice by Purkinje cells-specific Dyt1 knockout. ► Purkinje cells-specific knockout of Dyt1 as potential gene therapy for DYT1 dystonia. ► Intervening in the output signaling from the Purkinje cells as a possible therapy.