کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4313571 1290001 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Habituation within the somatosensory processing hierarchy
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Habituation within the somatosensory processing hierarchy
چکیده انگلیسی

Habituation is a basic process of learning evident in a decrement in neuronal/behavioral responses to repeated sensory stimulation. It is generally accepted that habituation affects all sensory systems in the human brain, including the somatosensory network. However, it is not clear where habituation originates within this hierarchically organized network. In this study, we examined whether habituation effects increase relatively uniformly along the processing hierarchy or rather distinctly at a particular processing stage. We addressed these questions by performing functional magnetic resonance imaging (fMRI) on 43 healthy subjects during unilateral electrical median nerve stimulation using a block design. We found a time-dependent decrease in the positive BOLD response (indicative of habituation) in all areas of the somatosensory network with the exception of Brodmann area (BA) 3b. The increase in habituation within the presumed processing stream was most pronounced between subareas of the primary somatosensory cortex (BA3b, BA1, BA2), and no further increase in habituation effects was observed in the subsequent processing stages within either the secondary somatosensory cortex or the insula. Moreover, we found a relatively strong habituation effect within the thalamus. These findings indicate that the increase in habituation along the processing hierarchy is measurable primarily between subareas of the primary somatosensory cortex, and we hypothesize that this increase originates in thalamocortical interactions early in the processing stream.


► It was investigated where within the somatosensory brain network neuronal habituation originates.
► fMRI was performed on 43 healthy subjects during somatosensory stimulation.
► Habituation is measureable primarily between subareas of the primary somatosensory cortex.
► Results indicate, that habituation originates mainly by thalamocortical interactions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 225, Issue 2, 1 December 2011, Pages 432–436
نویسندگان
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