Assessment of rewarding and reinforcing properties of biperiden in conditioned place preference in rats

Biperiden is one of the most commonly abused anticholinergic drugs. This study assessed its motivational effects in the acquisition of conditioned place preference in rats. Biperiden neither produced place conditioning itself nor enhanced the rewarding effect of morphine. Furthermore, biperiden in combination with haloperidol also did not affect place preference. These findings suggest that biperiden seems devoid of abuse potential properties at least at the doses used.

► Motivational effects of biperiden in the acquisition of CPP were assessed.
► The drug neither produces place conditioning itself nor potentiates the rewarding effect of morphine.
► It does not show an interaction with haloperidol also.
► Biperiden seems devoid of potential abuse properties at least at the doses used.