Coca-paste seized samples characterization: Chemical analysis, stimulating effect in rats and relevance of caffeine as a major adulterant

► In the present work we studied the stimulant effect of coca-paste (CP) seized samples. ► A chemical analysis was done to know the substances responsible for stimulant effect. ► We found that cocaine and caffeine were the main factors in the CP action. ► We provide valuable information related to the neuropharmacological action of CP.