کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4313729 | 1290007 | 2011 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The cholinergic system, EEG and sleep The cholinergic system, EEG and sleep](/preview/png/4313729.png)
Acetylcholine is a potent excitatory neurotransmitter, crucial for cognition and the control of alertness and arousal. Vigilance-specific recordings of the electroencephalogram (EEG) potently reflect thalamo-cortical and brainstem–cortical cholinergic activity that drives theta rhythms and task-specific cortical (de-synchronisation. Additionally, cholinergic projections from the basal forebrain act as a relay centre for the brainstem–cortical arousal system, but also directly modulate cortical activity, and thus promote wakefulness or rapid-eye movement (REM) sleep. Disease states such as sleep disorders, dementia and certain types of epilepsy are a further reflection of the potent cholinergic impact on CNS physiology and function, and highlight the relevance and inter-dependence of sleep and EEG. With novel technologies and computational tools now becoming available, advanced mechanistic insights may be gained and new avenues explored for diagnostics and therapeutics.
Research highlights
► The cholinergic system regulates vigilance stages and impacts on EEG spectral power.
► The link between CNS disorders, sleep and EEG is discussed.
► EEG and sleep phenotypes may offer therapeutic and diagnostic biomarkers.
Journal: Behavioural Brain Research - Volume 221, Issue 2, 10 August 2011, Pages 499–504