The potent inhibitory effect of tipepidine on marble-burying behavior in mice

▶ Tipepidine reduced MBB in a dose-dependent manner in mice. ▶ The tipepidine at 10 mg/kg s.c. nearly abolished MBB without reducing the locomotor activity. ▶ Dopamine D2 and 5-HT1A antagonists partly inhibited the effect of tipepidine. ▶ Tipepidine has a potent inhibitory effect on MBB, compared with known drugs used for the treatment of OCD, and that the tipepidine action mechanism might differ from that of known drugs.