Effects of acute amphetamine exposure on two kinds of Pavlovian approach behavior

Two kinds of Pavlovian conditioned approach behavior are possible: approach of the CS (sign-tracking) and approach of the US (goal-tracking). We hypothesized that administration of AMP would increase sign-tracking and decrease goal-tracking. However, increasing doses of AMP (up to 2.0 mg/kg) decreased measures of sign-tracking while simultaneously increasing measures of goal-tracking. Administration of AMP may shift responding from cues distant from the CS to cues closer to the CS.