کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4314557 1290040 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Immune involvement in schizophrenia and autism: Etiology, pathology and animal models
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Immune involvement in schizophrenia and autism: Etiology, pathology and animal models
چکیده انگلیسی

There is increasing evidence of immune involvement in both schizophrenia and autism. Of particular interest are striking abnormalities in the expression of immune-related molecules such as cytokines in the brain and cerebral spinal fluid (CSF). It is proposed that this represents a permanent state of brain immune dysregulation, which begins during early development. One possibility is that maternal infection, a known risk factor for schizophrenia and autism, sets this immune activation in motion. Several animal models are being used to investigate this hypothesis. There is also recent evidence that, among schizophrenic subjects, those associated with maternal infection display a distinctive pathology, which suggests that diverse causes for this disorder may explain some of its heterogeneity. The human and animal results related to immune involvement suggest novel therapeutic avenues based on immune interventions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 204, Issue 2, 7 December 2009, Pages 313–321
نویسندگان
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