کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4314835 | 1290050 | 2009 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Chronic effects of flunitrazepam on shock-induced behavioral inhibition in adult male rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
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چکیده انگلیسی
Flunitrazepam has been reported to trigger cases of extreme violence in man and recently it was shown to heighten aggression in experimental rats. The underlying mechanisms may involve disinhibited/impulsive behavior.Here, tolerance developed to the behavioral disinhibiting effect of flunitrazepam in Vogel's drinking conflict model, both in rats treated with flunitrazepam (0.32 mg/kg/day) for three weeks, as well as in rats treated for six weeks (0.32 mg/kg/day three weeks + 0.56 mg/kg/day three weeks).The results suggest that behavioral disinhibition is of limited importance in the mechanisms underlying the pro-aggressive effect of chronic flunitrazepam administration.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 199, Issue 2, 16 May 2009, Pages 360–363
Journal: Behavioural Brain Research - Volume 199, Issue 2, 16 May 2009, Pages 360–363
نویسندگان
Anders I. Svensson,