کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4314954 | 1290056 | 2009 | 7 صفحه PDF | دانلود رایگان |
Evidence suggests that a promoter polymorphism of the tryptophan-hydroxylase 2 gene (TPH2 −703 G/T) is associated with executive control functions. The current study aimed to clarify whether this relation is restricted to a purely cognitive domain or whether such an effect can also be observed in the processing of emotional material. In a sample of 89 student subjects, a ‘cognitive’ and an ‘emotional’ Stroop paradigm were applied to measure processing of cognitive and affective conflicts. Our results suggest an impact of the TPH2 −703 G/T polymorphism on executive control in both, the cognitive as well as the emotional task. In detail, homozygous carriers of the T allele showed decelerated responses in low-conflict conditions, pointing to a rather abnormal functioning of higher-order control mechanisms. Thus, the present investigation is consistent with previous behavioural studies and adds further evidence for the impact of serotonin at the interface of cognition and emotion.
Journal: Behavioural Brain Research - Volume 198, Issue 2, 17 March 2009, Pages 404–410