کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4315334 | 1290073 | 2007 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Neonatal basal forebrain cholinergic hypofunction affects ultrasonic vocalizations and fear conditioning responses in preweaning rats Neonatal basal forebrain cholinergic hypofunction affects ultrasonic vocalizations and fear conditioning responses in preweaning rats](/preview/png/4315334.png)
The present study investigated the effects of intracebroventricular injections of 192 IgG-saporin in 7-day-old rats on (i) ultrasound vocalizations (USVs) on postnatal day (pnd) 13 following isolation and reunion with the mother and (ii) fear conditioning on pnd 18–19 recording both freezing and other behavioural responses as well as USVs. On pnd 13 lesioned and control pups showed comparable USV baseline values; a brief reunion with the mother induced a significant increase in USVs in all rats (maternal potentiation). On pnd 18, during the fear conditioning training, 192 IgG-saporin rats emitted a lower number of USVs. On pnd 19 all rats showed a stronger conditioned response (with full inhibition of locomotion) to auditory than to contextual cues. Surprisingly, lesioned rats showed a stronger fear-conditioned response to contextual cues than controls. These results suggest that early selective removal of the cholinergic basal forebrain paradoxically enhances hippocampally dependent fear-conditioned responses on pnd 19.
Journal: Behavioural Brain Research - Volume 183, Issue 1, 1 October 2007, Pages 111–117