کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4315596 | 1290086 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Microinjection of the δ-opioid receptor selective antagonist naltrindole 5â²-isothiocyanate site specifically affects cocaine self-administration in rats responding under a progressive ratio schedule of reinforcement
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Whether the δ-opioid receptor (DOR) system can modulate behavioral effects of cocaine remains equivocal. We examined whether site- and subtype-selective blockade of DORs within the rat mesocorticolimbic system affects cocaine self-administration. The DOR antagonist naltrindole 5â²-isothiocyanate (5â²-NTII; 5 nmol) was microinjected into the nucleus accumbens (NAcc), ventral tegmental area (VTA), or amygdala (AMYG) in rats self-administering 1.5 mg/kg cocaine under a progressive ratio (PR) schedule. Intra-NAcc 5â²-NTII significantly decreased cocaine self-administration, while 5â²-NTII administration into the VTA significantly increased cocaine-maintained responding. 5â²-NTII administration into the AMYG produced no effect. These data support a site-specific role of DORs in cocaine's behavioral effects.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 182, Issue 1, 22 August 2007, Pages 140-144
Journal: Behavioural Brain Research - Volume 182, Issue 1, 22 August 2007, Pages 140-144
نویسندگان
Sara Jane Ward, David C.S. Roberts,