کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4315818 | 1613003 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Progressive deterioration of reaction time performance and choreiform symptoms in a new Huntington's disease transgenic ratmodel
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
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![عکس صفحه اول مقاله: Progressive deterioration of reaction time performance and choreiform symptoms in a new Huntington's disease transgenic ratmodel Progressive deterioration of reaction time performance and choreiform symptoms in a new Huntington's disease transgenic ratmodel](/preview/png/4315818.png)
چکیده انگلیسی
We tested the hypothesis that a recently developed transgenic rat model of Huntington's disease (tgHD rats) showed an age-and genotype-dependent change in psychomotor performance and in the frequency of choreiform movements similar to HD patients. Wild type and tgHD (homozygotic and heterozygotic) rats were behaviorally tested at an age of 15 and 20 months. Our results show that tgHD rats exhibit an age-, and genotype-dependent deterioration of the psychomotor performance and choreiform symptoms, closely mimicking the clinical time course changes of psychomotor symptoms of HD patients. These data provide further experimental evidence that the tgHD rat can be considered as a relevant animal model of HD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 170, Issue 2, 30 June 2006, Pages 257-261
Journal: Behavioural Brain Research - Volume 170, Issue 2, 30 June 2006, Pages 257-261
نویسندگان
Chunyan Cao, Yasin Temel, Arjan Blokland, Hatice Ozen, Harry W.M. Steinbusch, Rinske Vlamings, Huu Phuc Nguyen, Stephan von Hörsten, Christoph Schmitz, Veerle Visser-Vandewalle,