کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4315840 | 1290097 | 2006 | 7 صفحه PDF | دانلود رایگان |
Phencyclidine (PCP), a non-competitive NMDA receptor antagonist, was used to model schizophrenia-like cognitive dysfunctions of learning and memory in rats using the Morris water maze model for spatial memory. A protocol introduced by Baldi and co-workers was used to distinguish working memory from reference memory. Male Sprague–Dawley rats were administered PCP (2.0 mg/kg) before the first swimming trial on each of five spatial memory acquisition days, either alone or after pre-treatment with the nitric oxide synthase inhibitor, l-NAME (10 mg/kg). Probe tests for memory were conducted before and after each acquisition session. The results showed that PCP disrupted the acquisition of both working and reference memory. Pre-treatment with l-NAME reversed both these effects of PCP. l-NAME treatment by itself did not significantly alter either acquisition or retention of spatial memory.
Journal: Behavioural Brain Research - Volume 174, Issue 1, 1 November 2006, Pages 49–55