کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4315875 | 1290098 | 2007 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Muscimol inactivation of the septo-preoptic complex affects medial forebrain bundle self-stimulation only when directed at the complex's ventrolateral components
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
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![عکس صفحه اول مقاله: Muscimol inactivation of the septo-preoptic complex affects medial forebrain bundle self-stimulation only when directed at the complex's ventrolateral components Muscimol inactivation of the septo-preoptic complex affects medial forebrain bundle self-stimulation only when directed at the complex's ventrolateral components](/preview/png/4315875.png)
چکیده انگلیسی
Elements of the septo-preoptic basal forebrain complex, particularly the lateral and medial septum, the diagonal band of Broca, and the magnocellular preoptic area, have been linked to medial forebrain bundle (MFB) self-stimulation. This study examines the roles of these areas in MFB self-stimulation by temporarily inactivating them with 25 and 50Â ng doses of the GABAA receptor agonist muscimol. Changes in performance capacity and stimulation reward effectiveness were evaluated with the rate-frequency curve shift paradigm. When infused into the lateral and medial septum and the vertical limb of the diagonal band of Broca, both doses of muscimol were as ineffective as saline in altering either the rats' maximum rate of response for stimulation or the frequency required to maintain half-maximal response rate (required frequency). However, when infused into the horizontal limb of the diagonal band of Broca or the magnocellular preoptic area, muscimol substantially decreased maximal response rate and modestly increased required frequency. Changes in maximum rate were dose-dependent, but changes in required frequency were not. Muscimol infusions contralateral to the stimulated hemisphere were as effective as ipsilateral infusions; bilateral infusions tended to so suppress responding that resulting rate-frequency curves were often invalid. These results suggest a role in MFB self-stimulation for only the ventrolateral components of the septo-preoptic complex, and support past observations of considerable bilaterality in the neural systems that support self-stimulation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 178, Issue 1, 12 March 2007, Pages 98-107
Journal: Behavioural Brain Research - Volume 178, Issue 1, 12 March 2007, Pages 98-107
نویسندگان
Meg Waraczynski,