کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4315901 1290099 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Intrathecal administration of yohimbine impairs locomotion in intact rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Intrathecal administration of yohimbine impairs locomotion in intact rats
چکیده انگلیسی

The effects of upper lumbar level intrathecal injection of yohimbine, an α2-noradrenergic antagonist, on overground locomotion in intact rats was studied. This treatment caused dose-dependent impairment of hindlimb locomotor movement, which varied from transient hindlimb paralysis at a dose of 200 μg/20 μl to transient trunk instability at 50 μg/20 μl. Repetitive (every 48 h) injections of yohimbine at high (200 μg/20 μl) and medium (100 μg/20 μl) doses caused tachyphylaxis, which usually led to a lack of reaction to the third injection. This phenomenon was not observed after repetitive injections of the low (50 μg/20 μl) dose of the drug. These results show that the noradrenergic system is involved in the control of locomotion, since intrathecal administration of a specific antagonist affects this activity in intact rats.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 175, Issue 2, 15 December 2006, Pages 315–322
نویسندگان
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