کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4318669 1613235 2016 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neuronal nitric oxide synthase contributes to pentylenetetrazole-kindling-induced hippocampal neurogenesis
ترجمه فارسی عنوان
سنتاز اکسید نیتریک باعث ایجاد نروژنز هیپوکامپ ناشی از پنتیلن تترازول می شود
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
چکیده انگلیسی


• PTZ kindling up-regulates nNOS expression and its enzymatic activity.
• Selective Inhibition of nNOS decreased PTZ-kindling-induced new born cells proliferation in hippocampal DG.
• Selective Inhibition of nNOS suppressed PTZ-kindling-induced new born cells survival in hippocampal DG.

Neuronal nitric oxide synthase (nNOS), the major nitric oxide synthase isoform in the mammalian brain, is implicated in the pathophysiology of several neurological conditions, including epilepsy. Neurogenesis in hippocampal dentate gyrus (DG) persists throughout life in the adult brain. Alterations in this process occur in many neurological diseases, including epilepsy. Few studies, however, have addressed the role of nNOS in hippocampal DG neurogenesis in epileptic brain. The present study, therefore, investigated the role of nNOS in pentylenetetrazole (PTZ)-kindling-induced neurogenesis in hippocampal DG. Our results showed that nNOS expression and enzymatic activity were significantly increased in the hippocampus of PTZ-kindled mice. Meanwhile, these PTZ-kindled mice were characterized by significant enhancement of new born cells proliferation and survival in hippocampal DG, and these survived cells are co-labeled with NeuN and GFAP. Selective inhibition of nNOS by 7-NI, however, suppressed PTZ-kindling-induced hippocampal DG new born cells proliferation and survival, suggesting that nNOS contributes to PTZ-kindling-induced hippocampal neurogenesis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Bulletin - Volume 121, March 2016, Pages 138–147
نویسندگان
, , , , , ,