کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4319044 1613276 2011 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Vesicular acetylcholine transporter knock-down mice show sexual dimorphism on memory
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Vesicular acetylcholine transporter knock-down mice show sexual dimorphism on memory
چکیده انگلیسی

The key neural substrates involved in memory and cognitive tasks have been reported to receive important modulation from ovarian hormones. In fact, neurochemical systems associated with cognitive functions, such as the cholinergic system, are, at least in part, under modulation of estrogens. Here we show that vesicular acetylcholine transporter (VAChT) mutant mice, which express lower levels of the VAChT (VAChT KD) and reduced acetylcholine release, present sexual dimorphism on memory. We evaluate short- and long-term object recognition memories (STM and LTM) in both sexes. We have showed previously, and confirm here, that VAChT KDHET male mice present deficits in both STM and LTM object recognition memories in comparison with WT. In contrast, VAChT KDHET female mice present deficit in LTM, but not in STM. To test if the female hormones levels could be a determinant factor on sexual dimorphism observed, we submitted female mice to ovariectomy (OVX) or sham-surgery. After 1 week (1 w), we evaluate STM. Female hormone deprivation promotes STM impairment in VAChT KDHET, but not in WT female mice. Our results strongly suggest that the sexual dimorphism observed in VAChT KDHET mice on STM is due to modulation of cholinergic system by ovarian hormones.

Research highlights
► VAChT mutant mice present sexual dimorphism on memory.
► Object recognition memory is differentially modulated by cholinergic system.
► Ovarian hormones contribute to the sexual dimorphism observed in VAChT mutant.
► Female hormones can compensate cholinergic activity allowing for memory maintenance.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Bulletin - Volume 85, Issues 1–2, 25 April 2011, Pages 54–57
نویسندگان
, , , , ,