کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4319095 1290794 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antidepressant-like effects of urocortin 3 fragments
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Antidepressant-like effects of urocortin 3 fragments
چکیده انگلیسی

Urocortin 3 (Ucn 3) and various Ucn 3 fragments were tested with regard to antidepressive action in a modified forced swimming test following icv administration to mice. The fragment Ucn 3 (34–36) proved ineffective, whereas Ucn 3 (18–38), Ucn 3 (19–27), Ucn 3 (28–38), Ucn 3 (34–38), and Ucn 3 (36–38) demonstrated antidepressive-like action by shortening the immobility time and increasing the climbing and swimming times. The shortest molecule which elicited most of the antidepressive effects was the tripeptide Ucn 3 (36–38), H-Ala-Gln-Ile-NH2. The results indicate that the total sequence of Ucn 3 is not necessary for the antidepressive action of Ucn 3. Furthermore, the antidepresant actions of Unc3 (19–27) and Ucn 3 (36–38) can be blocked by the CRF2 receptor antagonist Astressin 2β.Establishment of the smallest active sequence of the molecule may allow the synthesis of analogs or mimetics for antidepressive drugs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Bulletin - Volume 84, Issue 6, 5 April 2011, Pages 414–418
نویسندگان
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