کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4319123 | 1613282 | 2010 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
[Glu2]TRH dose-dependently attenuates TRH-evoked analeptic effect in mice
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
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چکیده انگلیسی
Thyrotropin-releasing hormone (TRH, pGlu-His-Pro-NH2) and the structurally related [Glu2]TRH (pGlu-Glu-Pro-NH2) are endogenous peptides with a plethora of actions in the central nervous system. Many centrally-mediated effects of TRH are shared with those of [Glu2]TRH, although the involvement of different receptors is presumed. The analeptic action is the best-known TRH-related central nervous system effect. While [Glu2]TRH itself is analeptic, its co-administration with TRH into mice produced a dose-dependent attenuation of TRH-evoked reversal of barbiturate-induced sleeping time. This finding is in agreement with our previous observations that [Glu2]TRH significantly attenuates TRH-induced hippocampal extracellular acetylcholine release. Taken together, [Glu2]TRH may be considered as a negative modulator for the cholinergic effect of TRH in the mouse brain.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Bulletin - Volume 82, Issues 1â2, 29 April 2010, Pages 83-86
Journal: Brain Research Bulletin - Volume 82, Issues 1â2, 29 April 2010, Pages 83-86
نویسندگان
Vien Nguyen, Alevtina D. Zharikova, Katalin Prokai-Tatrai, Laszlo Prokai,