کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4319439 1290814 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of anti-histaminic and anti-cholinergic substances on human thermoregulation during cold provocation
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Effects of anti-histaminic and anti-cholinergic substances on human thermoregulation during cold provocation
چکیده انگلیسی

The roles of histaminergic and cholinergic neuron systems in the regulation of body temperature have been studied almost exclusively in animals. Recently, we have found that motion sickness, i.e. a condition where hippocampal cholinergic mismatch signals induce a release of histamine in the vomiting centre, accelerates the decline in body temperature in men during exposure to cold. In the present study we measured the thermoregulatory effects of two substances commonly used against motion sickness, i.e. the histamine (H1) receptor blocker dimenhydrinate (DMH) and the muscarine receptor blocker scopolamine (SCOP). In three trials, control (CN), DMH and SCOP, 10 male subjects were immersed in 15 °C water for a maximum of 90 min. The trials were separated by a minimum of three days and their order was alternated between subjects. In all trials the subject received, in a double blind fashion, a transdermal patch (SCOP or placebo) 12–14 h before immersion and a tablet (DMH or placebo) 1 h before immersion. Mean skin temperature, rectal temperature (Trec), the difference in temperature between the non-immersed right forearm and 3rd finger of the right hand (Tff), and oxygen uptake (VO2) were recorded. The fall in Trec was smaller in the DMH than in the CN and SCOP conditions. The recordings of Tff and VO2 suggest that SCOP attenuates peripheral vasoconstriction while DMH increases shivering thermogenesis. Notably, thermal discomfort was reduced in the SCOP condition. Findings are thoroughly discussed in the context of animal studies on the neuropharmacology and neurophysiology of thermoregulation and motion sickness.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Bulletin - Volume 81, Issue 1, 15 January 2010, Pages 100–106
نویسندگان
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